Focus
Focus on Cell biology of metabolism
Under physiological conditions, cells use a variety of pathways to generate energy and synthesize cellular building blocks including lipids, carbohydrates and nucleotides. Perhaps unsurprisingly, alterations in metabolic pathways have been implicated in many pathophysiological conditions. Indeed, cancer and normal cells differ dramatically in terms of their energy requirements and use of metabolic pathways. Obesity is essentially a metabolic disorder, and studies on the mechanisms underlying glucose metabolism and insulin resistance could lead the way to the development of new treatments for diabetes and obesity. Mitochondrial dysfunction and metabolic impairment is also thought to contribute to neurodegenerative diseases, such as Parkinson's and Alzheimer's. Thus, a complete understanding of how these biochemical metabolic pathways inform cell biological processes is critical for the prevention and treatment of these diseases. This web focus on the cell biology of metabolism presents a collection of research and review articles published in Nature Cell Biology in the past four years in this fast-moving field. The focus highlights our current knowledge on metabolism and its importance for normal physiology and disease.
Research
Metabolic differentiation in the embryonic retina
Michalis Agathocleous, Nicola K. Love, Owen Randlett, Julia J. Harris, Jinyue Liu, Andrew J. Murray and William A. Harris
DOI: 10.1038/ncb2531; Nature Cell Biology 14, 859–864; (2012)
Modulation of glutamine metabolism by the PI(3)K–PKB–FOXO network regulates autophagy
Kristan E. van der Vos, Pernilla Eliasson, Tassula Proikas-Cezanne, Stephin J. Vervoort, Ruben van Boxtel, Marrit Putker, Iris J. van Zutphen, Mario Mauthe, Sebastian Zellmer, Cornelieke Pals, Liesbeth P. Verhagen, Marian J. A. Groot Koerkamp, A. Koen Braat, Tobias B. Dansen, Frank C. Holstege, Rolf Gebhardt, Boudewijn M. Burgering and Paul J. Coffer
DOI: 10.1038/ncb2536; Nature Cell Biology 14, 829–837; (2012)
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration
Rhonda M. Perciavalle, Daniel P. Stewart, Brian Koss, John Lynch, Sandra Milasta, Madhavi Bathina, Jamshid Temirov, Megan M. Cleland, Stéphane Pelletier, John D. Schuetz, Richard J. Youle, Douglas R. Green and Joseph T. Opferman
DOI: 10.1038/ncb2488; Nature Cell Biology 14, 575–583; (2012)
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
Doris Berchtold, Manuele Piccolis, Nicolas Chiaruttini, Isabelle Riezman, Howard Riezman, Aurélien Roux, Tobias C. Walther and Robbie Loewith
DOI: 10.1038/ncb2480; Nature Cell Biology 14, 542–547; (2012)
Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila-
Jiwon Shim, Tina Mukherjee and Utpal Banerjee
DOI: 10.1038/ncb2453; Nature Cell Biology 14, 394–400; (2012)
Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia-
Wan Zhang, Dunyaporn Trachootham, Jinyun Liu, Gang Chen, Helene Pelicano, Celia Garcia-Prieto, Weiqin Lu, Jan A. Burger, Carlo M. Croce, William Plunkett, Michael J. Keating and Peng Huang
DOI: 10.1038/ncb2432; Nature Cell Biology 14, 276–286; (2012)
Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase-
Kambiz N. Alavian, Hongmei Li, Leon Collis, Laura Bonanni, Lu Zeng, Silvio Sacchetti, Emma Lazrove, Panah Nabili, Benjamin Flaherty, Morven Graham, Yingbei Chen, Shanta M. Messerli, Maria A. Mariggio, Christoph Rahner, Ewan McNay, Gordon C. Shore, Peter J. S. Smith, J. Marie Hardwick and Elizabeth A. Jonas
DOI: 10.1038/ncb2330; Nature Cell Biology 13, 1224–1233; (2011)
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration-
Claudio Mauro, Shi Chi Leow, Elena Anso, Sonia Rocha, Anil K. Thotakura, Laura Tornatore, Marta Moretti, Enrico De Smaele, Amer A. Beg, Vinay Tergaonkar, Navdeep S. Chandel & Guido Franzoso
DOI: 10.1038/ncb2324; Nature Cell Biology 13, 1272–1279; (2011)
E2F transcription factor-1 regulates oxidative metabolism-
Emilie Blanchet, Jean-Sébastien Annicotte, Sylviane Lagarrigue, Victor Aguilar, Cyrielle Clapé, Carine Chavey, Vanessa Fritz, François Casas, Florence Apparailly, Johan Auwerx & Lluis Fajas
DOI: 10.1038/ncb2309; Nature Cell Biology 13, 1146–1152; (2011)
Mir193b–365 is essential for brown fat differentiation
Lei Sun, Huangming Xie, Marcelo A. Mori, Ryan Alexander, Bingbing Yuan, Shilpa M. Hattangadi, Qingqing Liu, C. Ronald Kahn & Harvey F. Lodish
DOI: 10.1038/ncb2286; Nature Cell Biology 13, 958–965; (2011)
During autophagy mitochondria elongate, are spared from degradation and sustain cell viability-
Ligia C. Gomes, Giulietta Di Benedetto & Luca Scorrano
DOI: 10.1038/ncb2220; Nature Cell Biology 13, 589–598; (2011)
Lysosomal positioning coordinates cellular nutrient responses
Viktor I. Korolchuk, Shinji Saiki, Maike Lichtenberg, Farah H. Siddiqi, Esteban A. Roberts, Sara Imarisio, Luca Jahreiss, Sovan Sarkar, Marie Futter, Fiona M. Menzies, Cahir J. O'Kane, Vojo Deretic & David C. Rubinsztein
DOI: 10.1038/ncb2204; Nature Cell Biology 13, 453–460; (2011)
Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism-
Sabine D. Jordan, Markus Krüger, Diana M. Willmes, Nora Redemann, F. Thomas Wunderlich, Hella S. Brönneke, Carsten Merkwirth, Hamid Kashkar, Vesa M. Olkkonen, Thomas Böttger, Thomas Braun, Jost Seibler & Jens C. Brüning
DOI: 10.1038/ncb2211; Nature Cell Biology 13, 434–446; (2011)
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Kasey C. Vickers, Brian T. Palmisano, Bassem M. Shoucri, Robert D. Shamburek & Alan T. Remaley
DOI: 10.1038/ncb2210; Nature Cell Biology 13, 423–433; (2011)
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
Peng Jiang, Wenjing Du, Xingwu Wang, Anthony Mancuso, Xiang Gao, Mian Wu & Xiaolu Yang
DOI: 10.1038/ncb2172; Nature Cell Biology 13, 310–316; (2011)
The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis
Kirsten Kuhlbrodt, Philipp Christoph Janiesch, Éva Kevei, Alexandra Segref, Roja Barikbin & Thorsten Hoppe
DOI: 10.1038/ncb2200; Nature Cell Biology 13, 273–281; (2011)
O2 regulates stem cells through Wnt/β-catenin signalling
Jolly Mazumdar, W. Timothy O'Brien, Randall S. Johnson, Joseph C. LaManna, Juan C. Chavez, Peter S. Klein & M. Celeste Simon
DOI: 10.1038/ncb2102; Nature Cell Biology 12, 1007–1013; (2010)
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress
Sergei Chuikov, Boaz P. Levi, Michael L. Smith & Sean J. Morrison
DOI: 10.1038/ncb2101; Nature Cell Biology 12, 999–1006; (2010)
Asymmetrically inherited multidrug resistance transporters are recessive determinants in cellular replicative ageing
Amr Eldakak, Giulia Rancati, Boris Rubinstein, Parama Paul, Veronica Conaway & Rong Li
DOI: 10.1038/ncb2085; Nature Cell Biology 12, 799–805; (2010)
The CDK4–pRB–E2F1 pathway controls insulin secretion
Jean-Sébastien Annicotte, Emilie Blanchet, Carine Chavey, Irena Iankova, Safia Costes, Said Assou, Jacques Teyssier, Stéphane Dalle, Claude Sardet & Lluis Fajas
DOI: 10.1038/ncb1915; Nature Cell Biology 11, 1017–1023; (2009)
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1
Angel Herrero-Mendez, Angeles Almeida, Emilio Fernández, Carolina Maestre, Salvador Moncada & Juan P. Bolaños
DOI: 10.1038/ncb1881; Nature Cell Biology 11, 747–752; (2009)
Oct1 loss of function induces a coordinate metabolic shift that opposes tumorigenicity
Arvind Shakya, Robert Cooksey, James E. Cox, Victoria Wang, Donald A. McClain & Dean Tantin
DOI: 10.1038/ncb1840; Nature Cell Biology 11, 320–327; (2009)
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
Allyson E. Vaughn & Mohanish Deshmukh
DOI: 10.1038/ncb1807; Nature Cell Biology 10, 1477–1483; (2008)
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
Keiko Kawauchi, Keigo Araki, Kei Tobiume & Nobuyuki Tanaka
DOI: 10.1038/ncb1724; Nature Cell Biology 10, 611–618; (2008)
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
Kyu-Sun Lee, O-Yu Kwon, Joon H. Lee, Kisang Kwon, Kyung-Jin Min, Sun-Ah Jung, Ae-Kyeong Kim, Kwan-Hee You, Marc Tatar & Kweon Yu
DOI: 10.1038/ncb1710; Nature Cell Biology 10, 468–475; (2008)
Reviews
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism
Maria M. Mihaylova & Reuben J. Shaw
DOI: 10.1038/ncb2329; Nature Cell Biology 13, 1016–1023; (2011)
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