Research on one of the deadliest malignancies is yielding potentially game-changing insights — and treatments.

Brain cancer comprises only 2% of cancers, but is notoriously difficult to treat. Understanding the location of such tumours, as well as the underlying genetics, will help to tackle this devastating disease.

Could the latest immunotherapies succeed in tackling the deadliest form of brain cancer?

Neurological symptoms, as well as biological changes in cells and tissues, contribute to the disease’s characteristics, says Terri S. Armstrong.

Before they can get to work, treatments for brain cancer must bypass a formidable obstacle — the blood–brain barrier.

To find better treatments for brain cancer, an important step might be to grow mini-brains in the lab.

Other than ionizing radiation and genetics, little is known about the factors that influence a person’s chances of developing the disease.

Computer simulations of tumours could help doctors to choose the most effective approach to treatment.

A flood of sequencing data is enabling researchers to uncover how tumours differ from each other, and what such variation means for treatment strategies.

Brain tumours in children differ fundamentally from those in adults — a discovery with enormous implications for treatment strategies.

From lasers to electrical fields, clinicians are venturing off the beaten path to outflank a formidable foe.