Translational immunology in kidney disease
New technologies and improved understanding of immune processes have led to considerable advances in the treatment of autoimmune diseases; however, effective therapies for the treatment of immune–mediated kidney diseases are limited. This focus issue — published to coincide with the International Society of Nephrology's Nexus Symposium on translational immunology in kidney disease — aims to provide insights into new developments in the identification and targeting of appropriate therapeutic targets in immune–mediated kidney disease, and stimulate discussion as to how the translation of therapies to the clinic can be improved. The focus features four specially commissioned Reviews that describe hurdles to the application of new therapies for immune-mediated kidney disease; key therapeutic targets and their potential modulation by biologic therapies; targeting plasma cells in autoimmune renal disease and the use of mesenchymal stromal cells in renal transplantation.
