FOCUS
For hierarchy
OBESITY
Obesity is the primary health threat of the 21st century. The last 30 years have seen a dramatic increase in the prevalence of obesity, especially in the developed countries. Such an increase has played a significant role on the overall health of these nations, and, in turn, has led to significant increases in healthcare expenditure. The February 2012 issue contains a special feature on Obesity including articles by leading experts on several topics that relate to obesity etiology, animal models, therapeutics and clinical implications. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Nature Publishing Group.
Intervention and Prevention
Blood Pressure and Heart Rate Effects, Weight Loss and Maintenance During Long-Term Phentermine Pharmacotherapy for Obesity
Ed J. Hendricks, Frank L. Greenway, Eric C. Westman & Alok K. Gupta
Obesity 19: 2351–2360 (December 2011); doi:10.1038/oby.2011.94
Adipocyte Biology
Inducible Toll-like Receptor and NF-B Regulatory Pathway Expression in Human Adipose Tissue
Olga I. Vitseva, Kahraman Tanriverdi, Tamara T. Tchkonia, James L. Kirkland, Marie E. McDonnell, Caroline M. Apovian, Jane Freedman & Noyan Gokce
Obesity (2008) 16: 932–937; doi:10.1038/oby.2008.25
Perspective
Non-peptidic glucose-like peptide-1 receptor agonists: aftermath of a serendipitous discovery
Ming-wei Wang, Qing Liu & Cai-hong Zhou
ActaPharmacologicaSinica (2010) 31 : 1026–1030; doi:10.1038/aps.2010.107
Original Article
Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt
Chun-mei Zhang, Xiao-hui Chen, Bin Wang, Feng Liu, Xia Chi, Mei-ling Tong, Yu-hui Ni, Rong-hua Chen & Xi-rong Guo
ActaPharmacologicaSinica (2009) 30 : 120–124; doi:10.1038/aps.2008.9
Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study
F Thielecke, G Rahn, J Böhnke, F Adams, A L Birkenfeld, J Jordan & M Boschmann
European Journal of Clinical Nutrition 64, 704–713; doi:10.1038/ejcn.2010.47
The effects of dietary fibre on C-reactive protein, an inflammation marker predicting cardiovascular disease
C J North, C S Venter & J C Jerling
European Journal of Clinical Nutrition 63, 921–933; doi:10.1038/ejcn.2009.8
Prolonged exposure to resistin inhibits glucose uptake in rat skeletal muscles
Hong-qi Fan, Nan Gu, Feng Liu, Li Fei, Xiao-qin Pan, Mei Guo, Rong-hua Chen & Xi-rong Guo
ActaPharmacologicaSinica (2007) 28, 410–416; doi:10.1038/aps.2007.53
State of the Art
Obesity, Inflammation, and Cardiovascular Risk
P Mathieu, I Lemieux & J-P Després
Clinical Pharmacology & Therapeutics 87, 407–416; doi:10.1038/clpt.2009.311
Review
Transplantation of adipose tissue and stem cells: role in metabolism and disease
Thien T. Tran & C. Ronald Kahn
Nature Reviews Endocrinology 6, 195–213; doi:10.1038/nrendo.2010.20
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