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The Nature Biotechnology BioVision supplement contains a diverse set of articles that discuss the potential of biotechnology for improving the quality and duration of life in the coming millennium. Concomitant with the first BioVision meeting in Lyon, France, March 26-29, 1999, the supplement provides a forum for leaders in science, business, and social and cultural thinking to debate the importance of biotechnology in addressing global issues such as population growth, human health, the environment, and their societal, cultural, and political repercussions.