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Nature Immunology presents a series of specially commissioned articles discussing the newest insights into the tissue-specific characteristics of inflammation, the roles of microbiota and nutrition in driving inflammation, and the mechanistic and genetic bases of inflammation resolution and autoinflammation.
Netea and colleagues provide a general guide to the cellular and humoral contributors to inflammation as well as the pathways that characterize inflammation in specific organs and tissues.
Kastner and colleagues review monogenic autoinflammatory diseases and their molecular mechanisms and explore the overlap among autoinflammation, autoimmunity and immunodeficiency.
Kroemer and colleagues discuss the mechanisms through which nutrition modulates metabolic, microbial and neuroendocrine circuitries that affect cancer development and the response to treatment.
Magarian Blander and colleagues review the effects of the microbiome on innate and adaptive immunological players and how microbiota-derived bioactive molecules affect inflammation and the host response to infection, vaccination and cancer.
Beyaert, Karin and colleagues discuss the key molecular mechanisms that contribute to the self-limiting nature of inflammatory signaling, with emphasis on the negative regulation of the NF-κB pathway and the NLRP3 inflammasome.