Focus 04 March 2016

Breast

Modern Pathology and Laboratory Investigation are proud to present a special Web Focus highlighting recent advances in breast cancer diagnosis and treatment. We feature papers that describe testing guidelines, recommendations for standardized pathological evaluation, optimal specimen handling and management, factors affecting recurrence rate, the promise of immune-based therapy, and more.

Content

Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time
- Maria Vassilakopoulou
- Fabio Parisi
- Veronique M Neumeister
Research Article24 Nov 2014 Laboratory Investigation
Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition
- Gargi Maity
- Archana De
- Sushanta K Banerjee
Research Article13 Apr 2015 Laboratory Investigation
Loss of antigenicity with tissue age in breast cancer
- Susan E Combs
- Gang Han
- David L Rimm
Research Article16 Nov 2015 Laboratory Investigation
Impact of updated HER2 testing guidelines in breast cancer—re-evaluation of HERA trial fluorescence in situ hybridization data
- Oliver C Stoss
- Andreas Scheel
- Josef Rüschoff
Original Article25 Sep 2015 Modern Pathology
Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: a study of 63 cases from four different institutions
- Thaer Khoury
- Prasanna R Kumar
- Beatriu Reig
Original Article13 Nov 2015 Modern Pathology
Benign and low-grade fibroepithelial neoplasms of the breast have low recurrence rate after positive surgical margins
- Morgan L Cowan
- Pedram Argani
- Ashley Cimino-Mathews
Original Article8 Jan 2016 Modern Pathology
The immune microenvironment of breast ductal carcinoma in situ
- Elizabeth Thompson
- Janis M Taube
- Leisha A Emens
Original Article15 Jan 2016 Modern Pathology
Beyond immune density: critical role of spatial heterogeneity in estrogen receptor-negative breast cancer
- Sidra Nawaz
- Andreas Heindl
- Yinyin Yuan
Original Article27 Feb 2015 Modern Pathology
An international study to increase concordance in Ki67 scoring
- Mei-Yin C Polley
- Samuel C Y Leung
- on behalf of the International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group (BIG-NABCG)
Original Article20 Feb 2015 Modern Pathology
Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score
- Bradley M Turner
- Kristin A Skinner
- David G Hicks
Original Article1 May 2015 Modern Pathology
Reproducibility of residual cancer burden for prognostic assessment of breast cancer after neoadjuvant chemotherapy
- Florentia Peintinger
- Bruno Sinn
- W Fraser Symmans
Original Article1 May 2015 Modern Pathology
Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group
- Elena Provenzano
- Veerle Bossuyt
- on behalf of the Residual Disease Characterization Working Group of the Breast International Group-North American Breast Cancer Group (BIG-NABCG) collaboration
Original Article24 Jul 2015 Modern Pathology
Copy number analysis of ductal carcinoma in situ with and without recurrence
- Kylie L Gorringe
- Sally M Hunter
- Ian G Campbell
Original Article19 Jun 2015 Modern Pathology
Correlation of histopathologic features of ductal carcinoma in situ of the breast with the oncotype DX DCIS score
- Adriana Knopfelmacher
- Jana Fox
- Susan Fineberg
Original Article26 Jun 2015 Modern Pathology
Digital image analysis outperforms manual biomarker assessment in breast cancer
- Gustav Stålhammar
- Nelson Fuentes Martinez
- Johan Hartman
Original Article26 Feb 2016 Modern Pathology
MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer
- Lei Huo
- Yan Wang
- Zhuang Zuo
Original Article26 Feb 2016 Modern Pathology
Formalin-fixed, paraffin-embedded (FFPE) tissue epigenomics using Infinium HumanMethylation450 BeadChip assays
- Tim C de Ruijter
- Joep PJ de Hoon
- Jürgen Veeck
Technical Report13 Apr 2015 Laboratory Investigation
Critical roles of specimen type and temperature before and during fixation in the detection of phosphoproteins in breast cancer tissues
- Sibylle Gündisch
- Laura Annaratone
- Gianni Bussolati
Technical ReportOpen Access2 Mar 2015 Laboratory Investigation
Spectrally encoded confocal microscopy for diagnosing breast cancer in excision and margin specimens
- Elena F Brachtel
- Nicole B Johnson
- Dongkyun Kang
Technical Report18 Jan 2016 Laboratory Investigation
Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging
- Richard M Levenson
- Alexander D Borowsky
- Michael Angelo
Pathobiology in Focus2 Mar 2015 Laboratory Investigation

Breast

Content

Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time

Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition

Loss of antigenicity with tissue age in breast cancer

Impact of updated HER2 testing guidelines in breast cancer—re-evaluation of HERA trial fluorescence in situ hybridization data

Lobular neoplasia detected in MRI-guided core biopsy carries a high risk for upgrade: a study of 63 cases from four different institutions

Benign and low-grade fibroepithelial neoplasms of the breast have low recurrence rate after positive surgical margins

The immune microenvironment of breast ductal carcinoma in situ

Beyond immune density: critical role of spatial heterogeneity in estrogen receptor-negative breast cancer

An international study to increase concordance in Ki67 scoring

Use of modified Magee equations and histologic criteria to predict the Oncotype DX recurrence score

Reproducibility of residual cancer burden for prognostic assessment of breast cancer after neoadjuvant chemotherapy

Standardization of pathologic evaluation and reporting of postneoadjuvant specimens in clinical trials of breast cancer: recommendations from an international working group

Copy number analysis of ductal carcinoma in situ with and without recurrence

Correlation of histopathologic features of ductal carcinoma in situ of the breast with the oncotype DX DCIS score

Digital image analysis outperforms manual biomarker assessment in breast cancer

MicroRNA expression profiling identifies decreased expression of miR-205 in inflammatory breast cancer

Formalin-fixed, paraffin-embedded (FFPE) tissue epigenomics using Infinium HumanMethylation450 BeadChip assays

Critical roles of specimen type and temperature before and during fixation in the detection of phosphoproteins in breast cancer tissues

Spectrally encoded confocal microscopy for diagnosing breast cancer in excision and margin specimens

Immunohistochemistry and mass spectrometry for highly multiplexed cellular molecular imaging

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