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CHANNELOPATHY AND DRUG DISCOVERY
Channelopathies are diseases that result from functional disturbances of ion channels or the proteins that regulate them. The June special issue brings together a selection of articles dealing with the various ion channels, including aquaporins, potassium channels, chloride channels, sodium channels and calcium channels, that are involved in maladies such as cardiovascular disease, brain injury, reproductive disease and kidney disease and the recent advances that have been made in identifying potential drug targets for treating these diseases. The accompanying web focus presents additional links to related articles in this area from across Nature Publishing Group.
Articles
De novo expression of Trpm4 initiates secondary hemorrhage in spinal cord injury
Volodymyr Gerzanich, S Kyoon Woo, Rudi Vennekens, Orest Tsymbalyuk, Svetlana Ivanova, Alexander Ivanov, Zhihua Geng, Zheng Chen, Bernd Nilius, Veit Flockerzi, Marc Freichel & J Marc Simard
Nature Medicine 15: 185–191; doi:10.1038/nm.1899
Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia
Hong-Shuo Sun, Michael F Jackson, Loren J Martin, Karen Jansen, Lucy Teves, Hong Cui, Shigeki Kiyonaka, Yasuo Mori, Michael Jones, Joan P Forder, Todd E Golde, Beverley A Orser, John F MacDonald & Michael Tymianski
Nature Neuroscience 12: 1300–1307; doi:10.1038/nn.2395
Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans
Hiroshi Watanabe, Nagesh Chopra, Derek Laver, Hyun Seok Hwang, Sean S Davies, Daniel E Roach, Henry J Duff, Dan M Roden, Arthur A M Wilde & Björn C Knollmann
Nature Medicine 15: 380–383; doi:10.1038/nm.1942
TRPV1 shows dynamic ionic selectivity during agonist stimulation
Man-Kyo Chung, Ali D Güler & Michael J Caterina
Nature Neuroscience 11: 555–564; doi:10.1038/nn.2102
TMEM16A confers receptor-activated calcium-dependent chloride conductance
Young Duk Yang, Hawon Cho, Jae Yeon Koo, Min Ho Tak, Yeongyo Cho, Won-Sik Shim, Seung Pyo Park, Jesun Lee, Byeongjun Lee, Byung-Moon Kim, Ramin Raouf, Young Ki Shin & Uhtaek Oh
Nature 455: 1210–1215; doi:10.1038/nature07313
Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH
Jayasankar Jasti, Hiroyasu Furukawa, Eric B. Gonzales & Eric Gouaux
Nature 449: 316–323; doi:10.1038/nature06163
Structure of the formate transporter FocA reveals a pentameric aquaporin-like channel
Yi Wang, Yongjian Huang, Jiawei Wang, Chao Cheng, Weijiao Huang, Peilong Lu, Ya-Nan Xu, Pengye Wang, Nieng Yan & Yigong Shi
Nature 462: 467–472; doi:10.1038/nature08610
Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, 
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David Soto, Ian D Coombs, Massimiliano Renzi, Marzieh Zonouzi, Mark Farrant & Stuart G Cull-Candy
Nature Neuroscience 12: 277–285; doi:10.1038/nn.2266
Review
Autosomal dominant polycystic kidney disease: the last 3 years FREE
Vicente E Torres and Peter C Harris
Kidney Int 76: 149–168; doi:10.1038/ki.2009.128
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