Nature Structural & Molecular Biology | Editorial
Focus on Membrane Proteins
Membrane proteins are central to many physiological processes and are targeted by ~50% of marketed pharmaceutical drugs. Determining the structures of membrane proteins is essential for understanding their function and for drug design. This Focus highlights the latest breakthroughs in elucidating the structure and mechanisms of ABC transporters and neurotransmitter-gated ion channels; it also explores recent technical and methodological advances in X-ray crystallography, cryo-EM, NMR and computational approaches to investigate membrane proteins.