Human Organoids: Filling the Gap Between Basic and Translational Research
This Special Issue of Cell Death & Differentiation brings together a set of reviews focused on human organoids. Pioneers of the field discuss strategies to develop 3D cultures that faithfully recapitulate key features of human organs such as brain, inner ear, female reproductive or gastrointestinal tract, which can be used to study not only tissue physiology but also the pathogenic mechanisms of multiple diseases, ranging from infections to cancer. The authors discuss current challenges as well as strategies to harness the tremendous potential of organoids to fill the gap between basic and translational research.
