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Over recent years, there has been a renaissance of scientific research into psychedelic compounds and their effects on human physiology and mental wellbeing. Following the easing of research restrictions, a renewed interest in psychedelics has been driven by their potential application in treating conditions such as depression, anxiety, or post-traumatic stress disorder. This is particularly timely given the global rise in mental health problems, as such research may yield alternative treatments to traditionally used medication. This collection brings together some of the latest research on substances such as DMT, LSD and psilocybin and sheds some light on their action, their effects and their potential therapeutic use.