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Molecular determinants of intracellular infection

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Intracellular parasites and bacteria deploy an array of molecular tactics to invade host cells. Once inside, these pathogens subvert and co-opt host resources for survival and reproduction. Stealthy disguises help pathogens evade the immune response, and effector molecules enable a safe refuge for them to thrive. Equally, host cells defend, eliciting an arms race and intriguing battle involving a complex interplay of pathogen-host factors that shape the outcome of an infection. Unravelling such molecular determinants of intracellular infection promises a roadmap for developing novel therapeutics while illuminating the remarkable adaptability of life and the struggle for dominance at the tiniest scales.

For this Collection, we welcome any submissions focusing on pathogen-host biology and involving intracellular bacteria and parasites. Original research Articles characterising and validating molecular factors essential for pathogen growth in vitro and in vivo are welcome. In addition, we will also consider Reviews, Perspectives and Comments covering these topics. All submissions will be processed as regular Communications Biology Articles.

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Colour-rendered Scanning Electron Micrograph of T. gondii Tachyzoites Egressing from Human Host Cells.

Editors

Nishith Gupta is a Professor of Biological Sciences at the Birla Institute of Technology and Science, Hyderabad, India. Dr Gupta’s research focuses on understanding the molecular basis and network design principles of intracellular parasitism.

 

 

 

Karthika Rajeeve holds the position of Scientist E at the Rajiv Gandhi Centre for Biotechnology, India. The primary focus of Dr Rajeeve’s research is to unravel the mechanisms by which human pathogens, such as Chlamydia trachomatis and Mycobacterium tuberculosis, adeptly elude the vigilant surveillance of the host immune system.

 

 

 

Bang Shen is a Professor in the College of Veterinary Medicine at Huazhong Agricultural University, China. His research focuses on the metabolism and life cycle regulation of the ubiquitous parasite Toxoplasma gondii.