Transposable elements in health and disease
- Submission status
- Closed
- Submission deadline
Transposable elements are DNA sequences which are also known as “jumping genes”, given their ability to move from one location of the genome to another. They are present in all eukaryotic genomes and constitute roughly 50% of the human genome, making up the vast majority of what is often referred to as ”junk DNA”. Transposable elements are broadly categorised into two classes: retrotransposons (requiring transcription before being able to transpose) and DNA transposons. Transposable elements are drivers of genetic diversity and modulate gene expression and shape the genome’s architecture. They play critical roles in early mammalian development, regulation of stem cell properties and immune function. Dysregulated transposable element expression and function causes human monogenic diseases, and has been associated with neurological disease, autoimmune and inflammatory disorders, cancer, and normal aging. Technological advances in genome sequencing offer unprecedented opportunities to understand the effects of transposable elements on evolution and disease.
This Collection will gather articles that provide insight into transposable element expression and regulation, the physiological impacts of aberrant transposable element activity, and methodologies that enable probing their function.
Editors
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Maha MEZGHANI KHEMAKHEM
University of Tunis El Manar, Tunisia
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Sulev Koks
Murdoch University, Australia
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Fan Zhu
Wuhan University, China
Submitting a paper for consideration
To submit your manuscript for consideration at Scientific Reports as part of this Collection, please follow the steps detailed on this page. On the first page of our online submission system, under “I’m submitting:” select the option “any other article type”. Once logged in you can submit your manuscript to a Collection by selecting “Guest Edited Collection”, under the “Choose the appropriate manuscript type” message, and clicking “Continue”. Then when filling out the manuscript information, select the "Transposable elements in health and disease" Collection from the alphabetical list on the “Springer Nature Subject Category” tab. Authors should express their interest in the Collection in their cover letter.
Accepted papers are published on a rolling basis as soon as they are ready.
In addition to papers on Transposable elements in health and disease, Scientific Reports welcomes all original research in the field of Genetics. To browse our latest articles in Genetics click here.
