Molecular mechanisms of obesity
- Submission status
- Closed
- Submission deadline
Obesity is on the rise worldwide, affecting nearly one in eight adults and one in 14 children. Excess body fat increases the risk of heart disease, stroke, insulin resistance, diabetes, autoimmune disorders, some types of cancer, and other comorbidities. Despite the massive health and economic costs of obesity, the etiology of this condition at the molecular level is not fully understood. Mechanisms implicated in obesity include oxidative stress triggered by pro-inflammatory adipokines released by the adipose tissue, leading to insulin resistance; control of adipogenesis by long non-coding RNAs; epigenetic modifications; and changes in the gut microbiome leading to disrupted lipid and glucose homeostasis and satiety signaling.
The Collection will showcase articles that shed further light on the complex and varied causes of obesity, with an eye towards developing improved treatment and prevention strategies in the future.
Editors
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Antonio Brunetti
University of Catanzaro “Magna Græcia”, Italy
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Po-Shiuan Hsieh
National Defense Medical Center, Taiwan
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Petra Kotzbeck
Medical University of Graz, Austria
