Optical techniques for the recording and manipulation of neural activity in-vivo
- Submission status
- Closed
- Submission deadline
Optical methods have revolutionised the experimental measurement and control of neuronal populations. In optogenetics, the expression of light-activated opsin channels in cells enables investigators to initiate specific cellular events through the application of light as a precise activating signal. This allows us to understand the basic functioning of cells and neuronal pathways at a higher spatial and temporal resolution than before. In parallel, related optical methods have emerged that endow us with the ability to measure changes in cell activation through the release of fluorescent markers. These techniques afford either bulk or single-cell calcium imaging of neural activity with high temporal and spatial resolution in behaving animals.
Since the first exploration of optical techniques in the early 2000s, the experimental tools and methods have been repeatedly refined. Indeed, it has become more and more common that both recording and manipulation of neural activity using these techniques is performed within the same animal, providing a level of control and observation of neurons in a way we have never experienced. This Collection aims to gather research using the latest optical techniques in neuroscience, and what we've learned from their application.
Editors
-
Robert Krencik
Houston Methodist Hospital, USA
-
Talia Lerner
Feinberg School of Medicine - Northwestern University, USA
-
Xuelin Lou
Medical College of Wisconsin, USA
-
Melissa Sharpe
University of California, Los Angeles, USA
-
Hiromu Yawo
The University of Tokyo, Japan
Collections articles undergo Scientific Reports' standard peer review process and are subject to all of the journal’s standard policies. This includes the journal’s policy on competing interests. The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.
This Collection has not been supported by sponsorship.
