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Since the demonstration in 2012 that the viral CRISPR/Cas9 system can be used as a quick and flexible gene editing tool, the field of genetic engineering has undergone a massive revolution and opened new avenues of research in many other areas - in clinical sciences, in agriculture, in developmental biology. This Collection focuses on both the methodological advances in gene engineering using CRISPR/Cas-based systems but also other editing tools, as well as the applications of these gene engineering tools across any relevant disciplines.
Recent advances in genome editing technologies have redefined our ability to probe and precisely edit the human genome and epigenome in vitro and in vivo. More specifically, RNA-guided CRISPR/Cas systems have revolutionized the field due to their simplicity in design and adaptability across biological systems. This Collection highlights results in CRISPR/Cas technology that increase the efficiency of precision genome editing, and allow genetic manipulation in model systems traditionally intractable to site-directed gene modification.