Cellular senescence
- Submission status
- Open
- Submission deadline
Cellular senescence is induced by many cellular stressors and is accompanied by phenotypic changes, such as a stable proliferation arrest and the development of a pro-inflammatory secretome, also known as the senescence-associated secretory phenotype (SASP). Although the transient presence of senescent cells is beneficial in certain physiological functions, such as tumour suppression and wound healing, chronic accumulation of senescent cells in tissues has been implicated as a driver of aging and age-related diseases. Importantly, clearance of senescent cells has been shown to improve a variety of age-related pathologies. Therefore, development of therapies that target senescent cells (senotherapies) is an attractive strategy to improve organismal healthspan.
This Collection will feature articles focused on the role of cellular senescence in health and age-related diseases and will highlight the latest knowledge on the development of therapeutic strategies to target senescent cells.
This Collection supports and amplifies research related to SDG 3.
Editors
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Stella Victorelli, Ph.D
Research Associate, Assistant Professor of Physiology, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
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Larissa G. Prata, Ph.D
Research Associate, Robert and Arlene Kogod Center on Aging at Mayo Clinic, Rochester, Minnesota, USA.
