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NICOTINIC RECEPTORS AND NICOTINE ADDICTION
- Special issue:
- June 2009 Volume 30, No 6
Nicotinic acetylcholine receptors (nAChRs) are a superfamily of ligand-gated ion channels which mediate nicotine reward, dependence and addiction. Throughout the central nervous system, neuronal nAChRs exist as multiple, diverse subtypes comprising unique pentamers of genetically distinct subunits. These subtypes each exhibit different function and pharmacology, but their precise roles in nicotine addiction remain elusive. This special issue and accompanying web focus provide an overview of the possible mechanisms of different nAChR subtypes in the mediation of nicotine reward and reinforcement.
Articles
Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms FREE
Michael Graupner and Boris Gutkin
Acta Pharmacologica Sinica 30, 681–693 | doi:10.1038/aps.2009.87
Mechanism-based medication development for the treatment of nicotine dependence FREE
Zheng-xiong Xi, Krista Spiller and Eliot L Gardner
Acta Pharmacologica Sinica 30, 723–739 | doi:10.1038/aps.2009.46
Mysterious α6-containing nAChRs: function, pharmacology, and pathophysiology FREE
Ke-chun Yang, Guo-zhang Jin and Jie Wu
Acta Pharmacologica Sinica 30, 740–751 | doi:10.1038/aps.2009.63
Nicotinic mechanisms influencing synaptic plasticity in the hippocampus FREE
Andon Nicholas Placzek, Tao A Zhang and John Anthony Dani
Acta Pharmacologica Sinica 30, 752–760 | doi:10.1038/aps.2009.39
Pharmacological and immunochemical characterization of α2* nicotinic acetylcholine receptors (nAChRs) in mouse brain FREE
Paul Whiteaker, Jennifer A Wilking, Robert WB Brown, Robert J Brennan, Allan C Collins, Jon M Lindstrom and Jim Boulter
Acta Pharmacologica Sinica 30, 795–804 | doi:10.1038/aps.2009.68
New insights into the genetics of addiction
Ming D Li and Margit Burmeister
Nature Reviews Genetics 10, 225–231 | doi:10.1038/nrg2536
Abstract | Full Text | PDF (358KB) | Supplementary information
Acute nicotine reduces brain arachidonic acid signaling in unanesthetized rats
Lisa Chang, Stanley I Rapoport, Henry N Nguyen, Dede Greenstein, Mei Chen and Mireille Basselin
Journal of Cerebral Blood Flow & Metabolism 29, 648–658 | doi:10.1038/jcbfm.2008.159
Targeting nicotinic receptor antagonists as novel pharmacotherapies for tobacco dependence and relapse
Linda P Dwoskin and Michael T Bardo
Neuropsychopharmacology 34, 244–246 | doi:10.1038/npp.2008.157
Clinical Pharmacology of Nicotine: Implications for Understanding, Preventing, and Treating Tobacco Addiction
NL Benowitz
Clinical Pharmacology & Therapeutics, 83, 531–541 | doi:10.1038/clpt.2008.3
Translational research in medication development for nicotine dependence
Caryn Lerman, Mark G LeSage, Kenneth A Perkins, Stephanie S O'Malley, Steven J Siegel, Neal L Benowitz and William A Corrigall
Nature Reviews Drug Discovery, 6, 746–762 | doi:10.1038/nrd2361
The Role of Nicotinic Acetylcholine Receptors in the Primary Reinforcing and Reinforcement-Enhancing Effects of Nicotine
Matthew I Palmatier, Xiu Liu, Anthony R Caggiula, Eric C Donny and Alan F Sved
Neuropsychopharmacology, 32, 1098–1108 | doi:10.1038/sj.npp.1301228
Nicotine addiction and comorbidity with alcohol abuse and mental illness
John A Dani and R Adron Harris
Nature Neuroscience, 8, 1465–1470 | doi:10.1038/nn1580
Nicotinic receptors: Addiction's smoking gun?
Ann E Kelley
Nature Medicine, 8, 447–449 | doi:10.1038/nm0502-447
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