Tissue fibrosis and repair
- Submission status
- Closed
- Submission deadline
Fibrosis is a process of excess extracellular matrix deposition in response to injury that occurs where normal wound-healing processes have become dysregulated. This pathological deposition of tissue is due to an aberrant release of growth factors and cytokines and may lead to organ remodelling and dysfunction, contributing to chronic disease and organ failure. Though fibrosis occurs in tissues throughout the body, it is most commonly associated with severe disease when it occurs in the lungs, heart, liver and kidneys and is often not identified until organ function has been compromised.
This Collection aims to present manuscripts that increase our understanding of the mechanisms of tissue repair and causes of dysregulation or that present potential treatments that may slow disease progression.
Editors
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Qiang Ding
University of Alabama, USA
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Wendy M. Mars
University of Pittsburgh School of Medicine, USA
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Hideki Tatsukawa
Nagoya University, Japan
Qiang (John) Ding is a Professor at the University of Alabama. His research Interests include fibrosis, tissue injury, tissue repair and remodeling, cognition, and cancers. His research is mainly focused on cell matrix signaling, integrin function, cell migration and proliferation, cell differentiation and cell cycle, apoptosis and survival, gene transcription and translation, mitochondrial function and metabolism, and how cellular signaling is dysregulated. Prof Ding has been an Editorial Board Member for Scientific Reports since 2015.
Wendy M. Mars is an Associate Professor in the Department of Pathology at the University of Pittsburgh School of Medicine (UPSOM). She also serves as the Assistant Dean in the UPSOM Office of the Learning Environment and is Director of the Cellular and Molecular Pathology graduate program. Her current work focuses on factors related to tissue regeneration in the liver, especially as it relates to fibrosis/cirrhosis. Dr Mars has been an Editorial Board Member for Scientific Reports since 2015.
Hideki Tatsukawa is an Assistant Professor of Pharmaceutical Sciences at Nagoya University, Japan. His research areas include regulation of cellular responses involved in acute and chronic inflammation in the liver, kidney, and lung. His current work focuses on enzymes (for cross-linking of protein) to elucidate the molecular mechanism by which these enzymes involve epithelial cell homeostasis, cell death inflammation, and fibrosis. Dr Tatsukawa has been an Editorial Board Member for Scientific Reports since 2019.
