Collection 

Tissue fibrosis and repair

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Open
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Fibrosis is a process of excess extracellular matrix deposition in response to injury that occurs where normal wound-healing processes have become dysregulated. This pathological deposition of tissue is due to an aberrant release of growth factors and cytokines and may lead to organ remodelling and dysfunction, contributing to chronic disease and organ failure. Though fibrosis occurs in tissues throughout the body, it is most commonly associated with severe disease when it occurs in the lungs, heart, liver and kidneys and is often not identified until organ function has been compromised.

This Collection aims to present manuscripts that increase our understanding of the mechanisms of tissue repair and causes of dysregulation or that present potential treatments that may slow disease progression.

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Human cancer cells fibrosarcoma, micrograph.

Editors

Collection Scope

 

Fibrosis is a process of excess extracellular matrix deposition in response to injury that occurs where normal wound-healing processes have become dysregulated. This pathological deposition of tissue is due to an aberrant release of growth factors and cytokines and may lead to organ remodelling and dysfunction, contributing to chronic disease and organ failure. Though fibrosis occurs in tissues throughout the body, it is most commonly associated with severe disease when it occurs in the lungs, heart, liver and kidneys and is often not identified until organ function has been compromised.

This Collection aims to present manuscripts that increase our understanding of the mechanisms of tissue repair and causes of dysregulation or that present potential treatments that may slow disease progression.

 

Find out how to submit here