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Nature Milestones: Mass Spectrometry is a series of specially written articles, highlighting some of the most influential developments in the history of mass spectrometry and the chemical and biological applications that stemmed from these advances.
This Milestone is editorially independent, produced with financial support from a third party.
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Mass spectrometry has evolved and matured to a level where it is able to assess the complexity of the human proteome. We discuss some of the expected challenges ahead and promising strategies for success.