Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Long-term intervention with sorafenib induces hyper-expression of YAP thereby enhancing cell stemness and promoting the resistance. In our study, we found that in hepatocellular carcinoma tissues, MCM2 expression was highly correlated with YAP expression, and that MCM2 interference inhibited the Hippo signaling pathway by blocking YAP entry into the nucleus, thereby increasing cellular resistance to sorafenib.
Schematic presentation of the design of VEGFR targeting peptide conjugate (QR-KLU) and the antineoplastic efficacy of peptide QR-KLU in vitro and in vivo.