Collections

  • Series |

    The Clinical Subject category is edited by Professor Jeffry Evans (Glasgow, UK) and Professor Stephen Chia (Vancouver, Canada). See below for the latest research from this subject category.

    Image: JUAN GAERTNER/SCIENCE PHOTO LIBRARY; KATERYNA KON/SCIENCE PHOTO LIBRARY
  • Series |

    With an ever-growing body of oncology research, BJC Reviews seek to summarise and condense that information into thought-provoking commentaries. They cover a broad remit of oncology research, from the cellular and molecular events that underpin tumorigenesis and disease progression, to existing and emerging therapeutics and clinical cancer management. Our recent review articles are presented for you in this evolving Collection; we hope you enjoy reading them.

    Image: David Becker/ The Image Bank / Getty Images Plus
  • Collection |

    Programmed cell death 1 receptor (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) are immune checkpoint proteins found on the cell surface of T cells. Under physiological conditions their interaction results in T cell immune suppression, but cancer cells can hijack this pathway to escape immune detection. However, this can be reversed by blocking PD-1’s interaction with PD-L1. This has resulted in an intense research effort to investigate the underlying mechanisms and the clinical utility of inhibitors targeting these checkpoint proteins as therapeutic anticancer drugs. In this Collection we highlight a selection of recent papers focused on the cellular, molecular, diagnostic and clinical effects of these crucial proteins and their inhibitors.

    Image: Image taken from Sahin, I.H., Akce, M., Alese, O. et al. Br J Cancer 121, 809–818 (2019)
  • Collection |

    This Collection highlights the newest top-viewed content from BJC. Updated each month, we hope you enjoy reading this curated list of articles, which features content from across BJC’s six subject categories. BJC aims to serve as a forum for the sharing and discussion of developments in oncology, by publishing significant advances in translational and clinical cancer research, covering all aspects of cancer prevention, diagnosis, and treatment.

    Image: JUAN GAERTNER/SCIENCE PHOTO LIBRARY; KATERYNA KON/SCIENCE PHOTO LIBRARY
  • Collection |

    As an international journal, the British Journal of Cancer publishes articles on a wide range of cancer research from across the world. In this the first Regional Collection, we highlight a selection of recently published studies originating from authors residing in Asia, covering a wide range of subjects from clinical trials through to cell-based studies and from a variety of countries including China, Japan and South Korea and Taiwan among others.

  • Collection |

    As an international journal, the British Journal of Cancer publishes articles on a wide range of cancer research from across the world. In this Regional Collection, we highlight a selection of our top content from the USA. This collection covers the breadth of cancer research from clinical trials through to molecular and cellular-based studies and includes content from a range of top institutions such as Harvard University, Stanford University, and the Dana-Farber Cancer Institute.

    Image: JUAN GAERTNER/SCIENCE PHOTO LIBRARY; KATERYNA KON/SCIENCE PHOTO LIBRARY
  • Collection |

    On World Cancer Day , we present some of our top cited content from the last year. This selection reflects developing and ongoing trends in the cancer research community, including liquid biopsies, cancer metabolism, and our growing understanding of the immune system and immunotherapy. We hope you enjoy reading our Editor’s highlights, as we look forward to another year of exciting developments.

  • Special |

    Metabolic perturbations are a hallmark of cancer. Unique bioenergetic and biosynthetic alterations enable growth and metastasis in a nutrient-poor environment and understanding these modified pathways has been a key focus of research so far. We are now at a position where we need to develop these findings into preclinical and clinical outcomes, and this Special Issue on Cancer Metabolism highlights the ongoing challenges in the field. Curated by Professor Adrian Harris (University of Oxford) and Dr Christian Frezza (University of Cambridge), the Special Issue contains a selection of articles and commissioned content that provide insights into a variety of ongoing questions in oncometabolism, to help drive the translation of these findings towards the clinic.

    Image: Bill Longcore/Science Source
  • Collection |

    This new collection of breast cancer papers shows the wide range of clinical studies and translational research published in the British Journal of Cancer. Curated by our Editor-in-Chief, Adrian Harris (University of Oxford), the studies range from the difficult decisions of treating breast cancer, how people respond to a false positive test and to recent advances in BRCA1 and BRCA2 testing. Work on the role of oestrogen receptor status and BRCA2 and new work on triple receptor negative breast cancer, the androgen receptor and long-term outcome is presented. New genotypes and predictors of response to immunotherapy, as well as early phase studies on HDAC inhibitors are described. Although, not a novel agent, the important role of biosimilars is shown, and finally research on myc and metabolism in breast cancer.

    Image: Adrian Harris (University of Oxford)
  • Collection |

    The 2019 Nobel Prize in Physiology or Medicine was jointly awarded to William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza “for their discoveries of how cells sense and adapt to oxygen availability”. Collectively, their research led to an understanding of the elegant mechanism cells use to respond to changes in oxygen levels, a fundamental process that underpins normal physiologic functioning and plays a critical role in several diseases, including cancer. Via a combination of oxygen-dependant targeted destruction of the Hypoxia Inducible Factor and modulation of gene expression, cells are equipped to survive in a fluctuating environment. This pioneering research helped pave the way towards a plethora of medications that target this pathway. In celebration of their success, we have featured some of their articles in this collection, which includes content from Oncogene, British Journal of Cancer, Pediatric Research, Gene Therapy, Cell Death and Disease, and the Journal of Human Hypertension.

    Image: Emw [CC BY-SA 3.0 (https://creativecommons.org/licenses/by-sa/3.0)]
  • Collection |

    September is Childhood Cancer Awareness Month and in this Collection we highlight a selection of recent papers published in BJC focusing on research into children’s and young people’s cancers covering the epidemiology of cancer occurrence, insights into the molecular mechanisms underlying a variety of cancers affecting children and clinical trials highlighting potential treatments.