Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics

The Pharmacogenomics Journal volume 16, pages 79–82 (2016)Cite this article

Subjects

Abstract

Genetic predictors of beta-lactam (BL) allergy are mostly related to Immunoglobulin E (IgE) synthesis and atopy. Despite this context, little attention has been devoted to genes of IgE/FcɛRI pathway, such as galectin-3, a β-galactoside-binding lectin, which binds to IgE. We evaluated the association of LGALS3 polymorphisms with BL allergy in 395 Spanish and 198 Italian cases, compared with 310- and 339-matched controls, respectively. The rs11125 predicted BL allergy with an odds ratio of 4.0 in Spanish population (P<0.0001). This association was replicated with an odds ratio of 5.1 in Italian population (P<0.0001); rs11125 predicted also increased serum level of total IgE in Spanish controls. These data are consistent with the predicted deleterious influence of Gln>His substitution produced by rs11125 on galactose-binding activity of galectin-3. In conclusion, LGALS3 is the strongest genetic predictor of BL allergy reported so far. This association reflects the influence of genes of IgE/FcɛRI pathway in this pathology.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Gomes ER, Demoly P . Epidemiology of hypersensitivity drug reactions. Curr Opin Allergy Clin Immunol 2005; 5: 309–316.

    Article  PubMed  Google Scholar 

  2. Gueant JL, Gueant-Rodriguez RM, Viola M, Valluzzi RL, Romano A . IgE-mediated hypersensitivity to cephalosporins. Curr Pharm Des 2006; 12: 3335–3345.

    Article  CAS  PubMed  Google Scholar 

  3. Gueant JL, Gueant-Rodriguez RM, Gastin IA, Cornejo-Garcia JA, Viola M, Barbaud A et al. Pharmacogenetic determinants of immediate and delayed reactions of drug hypersensitivity. Curr Pharm Des 2008; 14: 2770–2777.

    Article  CAS  PubMed  Google Scholar 

  4. Cornejo-Garcia JA, Gueant-Rodriguez RM, Torres MJ, Blanca-Lopez N, Tramoy D, Romano A et al. Biological and genetic determinants of atopy are predictors of immediate-type allergy to betalactams, in Spain. Allergy 2012; 67: 1181–1185.

    Article  CAS  PubMed  Google Scholar 

  5. Qiao HL, Yang J, Zhang YW . Relationships between specific serum IgE, cytokines and polymorphisms in the IL-4, IL-4Ralpha in patients with penicillins allergy. Allergy 2005; 60: 1053–1059.

    Article  CAS  PubMed  Google Scholar 

  6. Gueant-Rodriguez RM, Romano A, Beri-Dexheimer M, Viola M, Gaeta F, Gueant JL . Gene-gene interactions of IL13 and IL4RA variants in immediate allergic reactions to betalactam antibiotics. Pharmacogenet Genomics 2006; 16: 713–719.

    Article  CAS  PubMed  Google Scholar 

  7. Guglielmi L, Fontaine C, Gougat C, Avinens O, Eliaou JF, Guglielmi P et al. IL-10 promoter and IL4-Ralpha gene SNPs are associated with immediate beta-lactam allergy in atopic women. Allergy 2006; 61: 921–927.

    Article  CAS  PubMed  Google Scholar 

  8. Qiao HL, Yang J, Zhang YW . Specific serum IgE levels and FcepsilonRIbeta genetic polymorphism in patients with penicillins allergy. Allergy 2004; 59: 1326–1332.

    Article  CAS  PubMed  Google Scholar 

  9. Gueant JL, Romano A, Cornejo-Garcia JA, Oussalah A, Chery C, Viola M et al. HLA-DRA variants predict penicillin allergy in genomewide fine-mapping genotyping. J Allergy Clin Immunol 2014; 135: 253–259.

    Article  PubMed  Google Scholar 

  10. Gould HJ, Sutton BJ . IgE in allergy and asthma today. Nat Rev Immunol 2008; 8: 205–217.

    Article  CAS  PubMed  Google Scholar 

  11. Chen HY, Sharma BB, Yu L, Zuberi R, Weng IC, Kawakami Y et al. Role of galectin-3 in mast cell functions: galectin-3-deficient mast cells exhibit impaired mediator release and defective JNK expression. J Immunol 2006; 177: 4991–4997.

    Article  CAS  PubMed  Google Scholar 

  12. Saegusa J, Hsu DK, Chen HY, Yu L, Fermin A, Fung MA et al. Galectin-3 is critical for the development of the allergic inflammatory response in a mouse model of atopic dermatitis. Am J Pathol 2009; 174: 922–931.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Bursztejn AC, Romano A, Guéant-Rodriguez RM, Cornejo JA, Oussalah A, Chery C et al. Allergy to betalactams and nucleotide-binding oligomerization domain (NOD) gene polymorphisms. Allergy 2013; 68: 1076–1080.

    Article  CAS  PubMed  Google Scholar 

  14. Torres MJ, Blanca M, Fernandez J, Romano A, Weck A, Aberer W et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy 2003; 58: 961–972.

    Article  CAS  PubMed  Google Scholar 

  15. deBoer RA, Verweij N, van Veldhuisen DJ, Westra HJ, Bakker SJ, Gansevoort RT et al. A genome-wide association study of circulating galectin-3. PLoS One 2012; 7: e47385.

    Article  CAS  Google Scholar 

  16. Nam YH, Kim JE, Kim SH, Jin HJ, Hwang EK, Shin YS et al. Identifying genetic susceptibility to sensitization to cephalosporins in health care workers. J Korean Med Sci 2012; 27: 1292–1299.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Cornejo-Garcia JA, Fernandez TD, Torres MJ, Carballo M, Hernan I, Antunez C et al. Differential cytokine and transcription factor expression in patients with allergic reactions to drugs. Allergy 2007; 62: 1429–1438.

    Article  CAS  PubMed  Google Scholar 

  18. Platzer B, Ruiter F, van der Mee J, Fiebiger E . Soluble IgE receptors—elements of the IgE network. Immunol Lett 2011 30; 141: 36–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Dr Cornejo-García is a postdoctoral researcher and Pr Miguel Blanca is visiting full professor at the Medical Faculty, University of Nancy. Manuscript was supported in part by Grants from Inserm, the Lorraine Region and PHRC (Hospital clinical research program, 2012, PHRC 189), and from Spanish Ministry Fund for Health in Spain (FIS) network RIRAAF (RD12/0013), and PS09/02419.

Author information

Author notes

  1. J A Cornejo-García, A Romano and R M Guéant-Rodríguez: These authors contributed equally to this work.

Authors and Affiliations

  1. INSERM U-954, University of Lorraine and University Hospital Center (CHU) of Nancy, Nancy, France

    J A Cornejo-García, R M Guéant-Rodríguez, A Oussalah, D Tramoy, T Josse & J-L Guéant

  2. Research Laboratory, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain

    J A Cornejo-García

  3. Allergy Unit, IBIMA, Regional University Hospital of Malaga, UMA, Malaga, Spain

    J A Cornejo-García, I Doña, M J Torres & M Blanca

  4. Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, Complesso Integrato Columbus, Rome and IRCCS Oasi Maria S.S., Troina, Italy

    A Romano & F Gaeta

  5. Allergy Service, Infanta Leonor Hospital, Madrid, Spain

    N Blanca-López & G Canto

Authors
  1. J A Cornejo-García
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A Romano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. R M Guéant-Rodríguez
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A Oussalah
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N Blanca-López
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F Gaeta
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D Tramoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. T Josse
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. I Doña
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M J Torres
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. G Canto
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. M Blanca
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. J-L Guéant
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J-L Guéant.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Supplementary Information accompanies the paper on the The Pharmacogenomics Journal website

Supplementary information

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cornejo-García, J., Romano, A., Guéant-Rodríguez, R. et al. A non-synonymous polymorphism in galectin-3 lectin domain is associated with allergic reactions to beta-lactam antibiotics. Pharmacogenomics J 16, 79–82 (2016). https://doi.org/10.1038/tpj.2015.24

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/tpj.2015.24

This article is cited by

Search

Advanced search

Quick links