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Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma

The Pharmacogenomics Journal volume 13, pages 523–529 (2013)Cite this article

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Abstract

Recent genome-wide association studies linked childhood asthma with single-nucleotide polymorphisms (SNPs) in ORM1-like protein 3 (ORMDL3) gene region on chromosome 17q21. We analyzed the effect of functional SNP rs2872507 in ORMDL3 gene region on the response to antiasthmatic treatment with inhaled corticosteroids (ICSs) and ORMDL3 gene expression. Forced expiratory volume in 1 s increased significantly by 13.3% of predicted value after therapy in atopic asthmatics with AA genotype, compared with 7.0% in heterozygotes and 4.9% increase in GG homozygotes (P=0.0176). Median relative expression of ORMDL3 gene in asthmatics with AA, AG and GG genotypes was 0.75, 1.05 and 1.21, respectively (P<0.0001). Treatment with ICSs was significantly associated with the increase of median relative expression of ORMDL3 gene, from 0.88 to 1.21 (P=0.0032) in atopic asthmatics. Our results suggest that rs2872507 is associated with ORMDL3 gene expression and with ICS treatment response in children with atopic asthma.

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Acknowledgements

This work was supported by Slovenian Research Agency Grant No. P3–0067. No other supporting source or sponsors have been involved in the study design, data management, writing of the report or decision to submit the manuscript for publication.

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Authors and Affiliations

  1. Department of Pediatrics, University Medical Centre Maribor, Maribor, Slovenia

    V Berce

  2. Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia

    C E P Kozmus & U Potočnik

  3. Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal

    C E P Kozmus

  4. Laboratory for Biochemistry Molecular Biology and Genomics, Faculty for Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia

    U Potočnik

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Correspondence to U Potočnik.

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Berce, V., Kozmus, C. & Potočnik, U. Association among ORMDL3 gene expression, 17q21 polymorphism and response to treatment with inhaled corticosteroids in children with asthma. Pharmacogenomics J 13, 523–529 (2013). https://doi.org/10.1038/tpj.2012.36

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