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eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension

The Pharmacogenomics Journal volume 10, pages 40–45 (2010)Cite this article

Abstract

Variations of the endothelial nitric oxide synthase (eNOS) gene have been associated with hypertensive disorders of pregnancy. We examined whether eNOS polymorphisms affect the therapeutic responses of women with gestational hypertension (GH) or preeclampsia (PE). We studied 304 hypertensive pregnant women (152 GH and 152 PE), who were stratified according to clinical and laboratorial parameters of therapeutic responsiveness. We compared the frequencies of three eNOS genetic polymorphisms (T-786C, Glu298Asp and b/a intron 4) in responsive and nonresponsive PE and GH patients. We found no significant differences in genotype or allele distributions when responsive and nonresponsive groups were compared (both PE or GH; all P>0.05). However, the eNOS haplotype distribution differed in PE (but not in GH)-responsive and -nonresponsive groups (P=0.0003). The ‘C-Glu-a’ and ‘T-Asp-a’ hapotypes were associated with responsiveness and nonresponsiveness to therapy, respectively (both P<0.001), thus suggesting that eNOS haplotypes affect the responsiveness to antihypertensive therapy in PE.

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Acknowledgements

This study was supported by Fundação de Amparo à Pesquisa do Estado de Sao Paulo (FAPESP), by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and by Coordenadoria de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

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Authors and Affiliations

  1. Santa Casa de Belo Horizonte, Av. Francisco Sales 1111, Belo Horizonte, MG, Brazil

    V C Sandrim

  2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, SP, Brazil

    V C Sandrim, M R Luizon, T C Izidoro-Toledo & J E Tanus-Santos

  3. Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, Campinas, SP, Brazil

    A C T Palei

  4. Department of Gynecology and Obstetrics, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, Ribeirao Preto, SP, Brazil

    R C Cavalli

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  1. V C Sandrim
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Correspondence to J E Tanus-Santos.

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Sandrim, V., Palei, A., Luizon, M. et al. eNOS haplotypes affect the responsiveness to antihypertensive therapy in preeclampsia but not in gestational hypertension. Pharmacogenomics J 10, 40–45 (2010). https://doi.org/10.1038/tpj.2009.38

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  • DOI: https://doi.org/10.1038/tpj.2009.38

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