Abstract
Adult neuroblastoma (ANB) is an uncommon malignancy, there being only 42 reported cases in the world literature. The purpose of this report is to present a case of ANB with spinal cord compression by an intraspinal component, and review methods of diagnosis and treatment.
NB is one of the most frequent childhood malignancies (90% of the patients are less than 10 years old) and both pathologists and clinicians tend to exclude it from differential diagnosis when the patient is an adult.
When the tumour is located in the paraspinal region, local extension through the intervertebral foramen into the spinal canal can occur in a dumbbell fashion, a pattern of growth first described by Weber in 1856.
References
Akwari O E, Spencer, W, Payne, B et al, 1978 Dumbbell Neurogenic Tumours of the Mediastinum. 53: 353–358. Mayo Clinic Proceedings
Aleshire, S L, Glick A D, Cruz V E, et al 1985 Neuroblastoma in Adults: Pathologic findings and clinical Outcome. Patholological Laboratory Medicine 109: 352–356.
Allan S G, Cornbleed M A, Carmichael J, et al 1986 Adult Neuroblastoma. Report of three cases and Review of the literature. Cancer 57: 2419–2421.
Salakrisshnan V, Rice M S, Simpson D A 1974 Spinal Neuroblastomas. Diagnosis, Treatment and Prognosis Journal of Neurosurgery 40: 631–638.
Beemer F A, Vlug A M C, Vanveelen C W M, et al 1984 Isoenzyme pattern of enolase of childhood tumors. Cancer 54: 293–296.
Berliner P, Unsicker K 1985 Tetanus Toxin Labeling as a novel rapid and highly specific tool in human neurobl stoma differential diagnosis. Cancer 56: 419–423.
Cohen M D, Weetman R, Provisor A, et al 1984 Magnetic Resonance Imaging (MRI) of neuroblastoma with a D.15 T Magnet American Journal of Roentgenology 143: 1241–1243.
Coldman A J, Fryer C S H, El Wood J M, et al 1980 Neuroblastoma: Influence of age at diagnosis, stage, tumor site, and sex on prognosis. Cancer 46: 1896–1901.
Dietrich R B, Kangarloo H 1986 Retroperitoneal mass with intradural extension: Value of Magnetic Resonance Imaging in Neuroblastoma. American Journal of Roentgenology 146: 251–254.
Dosik G H, Rodriguez V, Benjamin R S, et al 1978 Neuroblastoma in adult. Effective combination chemotherapy. Cancer 41: 56–63.
Eto H 1986 Adult Neuroblastoma: A case report. Hinyokika Kiyo 32(9): 1294-1297.
Evans A, Albo V, O'Angio G J, et al 1975 Factors Influencing Survival of children with nonmetastasic Neuroblastoma. Cancer 38: 661–666.
Evans A 1980 Staging and Treatment of neuroblastoma. Cancer 45: 1799–1802.
Evans A, D'Angio G J, Propert K, et al 1987 Prognostic factors in neuroblastoma. Cancer 59: 1853–1859.
Fagan C J, Swischuck L E 1974 Dumbell neuroblastoma or Ganglioneuroma of the spinal canal. American Journal of Roentgenology 120: 453–460.
Gitlow S E, Bertani L M, Rausen A, et al 1970 Diagnosis of Neuroblastoma by qualitative and quantitative determination of catecholamine metabolites in urine. Cancer 1377–1383.
Hann H W L, Levy H R, Evans A E 1980 Serum ferritin as a Guide to therapy in Neuroblastoma. Cancer Research 40: 1411–1413.
Hashimoto H, Enjoji M, Nakajima T, et al 1983 Malignant neuroepithelioma (Peripheral Neuroblastoma): A Clinicopathological study of 15 cases. American Journal of Surgery and Pathology 7: 309–318.
Holgersen L O, Santuli T V, Schullinger J N, et al 1983 Neuroblastoma with intraspinal (dumbbell) extension. Journal of Pediatric Surgery 18: 406–411.
Holperin E C 1986 Radiation therapy in the management of Neuroblastoma. The Duke University Medical Center experience. International Journal of Radiation, Oncology, Biology, Physics 12(10): 1829–1837.
Hughes M, Mardsen H B, Palmer M K 1974 Histologic patterns of Neuroblastoma related prognosis and clinical staging. Cancer 34: 1706–1711.
Kaye J A, Warhol M J, Kretschmar C, et al 1986 Neuroblastoma in adults. Tree case reports and a review of literature. Cancer 58: 1149–1157.
Kinnier Wilson L M, Draper G J 1974 Neuroblastoma its natural history and prognosis. A study of 487 cases. British Medical Journal 3: 301–307.
King D, Goodman J, Haluk T, et al 1975 Dumbbell Neuroblastomas in children. Archives of Surgery 110: 888–891.
Ladish S, Liang Lu Z 1985 Detection of a tumor associated ganglioside in plasma of patients with neuroblastoma. The Lancet 19.
Lopez R, Karakousis C, Rao U 1980 Treatment of Adult neuroblastoma. Cancer 45: 840–844.
Mackay B, Luna M A, Butler J 1976 Adult Neuroblastoma. Electron Microscopic observations in nine cases. Cancer 37: 1334–1351.
Massad M, Haddad F, Slim M, et al 1985 Spinal cord compression in Neuroblastoma. Surgical Neurology 23: 567–572.
Misugi K, Misugi N, Newton W A 1968 Fine structural study of neuroblastoma, ganglioneuroblastoma and pheocromocytoma. Archives of Pathology 86: 160–170.
Punt J, Pritchard J, Pincott J R, et al 1980 Neuroblastoma: A review of 21 cases presenting with spinal cord compression. Cancer 45: 3095–3101.
Resjo I M, Hardwood-Nash D C, Fitz C R, et al 1979 CT Metrizamide myelography for intraspinal and paraspinal neoplasms in infants and children. American Journal of Roentgenology 132: 367–372.
Reyne J 1986 Dumbbell Neuroblastoma presenting without spinal cord findings. Journal Pediatric Surgery 21(11): 995–996.
Reynolds C P, Smith G, Frenkel E P 1981 The diagnostic dilemma of ‘small round cell neoplasm.’ Cancer 38: 2008–2034.
Shimada H, Chatlen J, Newton W A 1984 Histopathologic prognostic factors in neuroblastic tumors. Journal of the National Cancer Institute 73: 405–416.
Siegel: M J, Jamroz G A, Glazer H S, et al 1986 Imaging of intraspinal extension of neuroblastoma. Journal of Computer Assisted Tomography 10: 593–595.
Simone J V, Cassady J R, Filler R M 1982 Cancers of childhood. In: VT De Vita, S Hellmann S Rsenberg (Eds) Cancer: Principles and Practice of Oncology. Lippincott, Philadelphia, pp 1254–1330.
Triche T J, Askin F B 1983 Neuroblastoma and the differential diagnosis of small round, blue-cell tumors. Human Pathology 569–595.
Vinores S A, Sonnin J M, Rubinstein L J, et al 1984 Immunohistochemical demonstration of NSE in neoplasms of the CNS and other tissues. Archives of Pathology and Laboratory Medicine 108: 536–540.
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Urios, J., Garceran, L. & Rosell, T. Neuroblastoma in an adult causing spinal cord compression: report of a case and review of the literature. Spinal Cord 27, 394–401 (1989). https://doi.org/10.1038/sc.1989.62
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DOI: https://doi.org/10.1038/sc.1989.62
Keywords
- Adult neuroblastoma
- Dumbbell neuroblastoma
- Spinal cord compression
