A method of studying the effect of drugs on the lower urinary tract is described, using cord-injured patients with detrusor hyperreflexia. In this study 19 patients received intravenous phentolamine. This alpha-adrenergic blockade produced a significant reduction in the maximum voiding detrusor pressure, voided volumes and peak flow rates with no reduction of outflow tract obstruction.
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Thomas, D., Philp, N., McDermott, T. et al. The use of urodynamic studies to assess the effect of pharmacological agents with particular references to alpha-adrenergic blockade. Spinal Cord 22, 162–167 (1984). https://doi.org/10.1038/sc.1984.29
- Reflex micturition
- Alpha-adrenergic blockade
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