The clinical translation of therapeutics on the basis of human gut microorganisms is hampered by our limited knowledge of how microbes survive and adapt to fluctuating conditions in the gut. The systematic exploration of gut microbiome survival strategies and trade-offs will thus enable the design of more efficient microbiome-based interventions.
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Acknowledgements
We would like to thank the members of the Lab for Microbial Systems Biology for helpful discussions and apologize to all authors whose work could not be included due to space constraints.
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The manuscript was written by B.L., D.R.G. and K.F., with minor contributions from X.Z. and P.S.
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Liu, B., Garza, D.R., Saha, P. et al. Exploiting gut microbial traits and trade-offs in microbiome-based therapeutics. Nat Rev Bioeng (2024). https://doi.org/10.1038/s44222-024-00178-1
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DOI: https://doi.org/10.1038/s44222-024-00178-1
