A large-scale prospective cohort study with 287,282 participants revealed that the integration of multiple healthy lifestyle factors (a favorable lifestyle) was associated with a lower risk of depression. Categorizing participants on the basis of their polygenic risk scores for depression demonstrated that the effect of this favorable lifestyle persisted even among participants with high genetic susceptibility.
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References
Malhi, G. S. & Mann, J. J. Depression. Lancet 392, 2299–2312 (2018). This review article presents the epidemiology and pathology of depression.
Marwaha, S. et al. Novel and emerging treatments for major depression. Lancet 401, 141–153 (2023). This review article presents drawbacks in treating depression.
Lassale, C. et al. Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies. Mol. Psychiatry 24, 965–986 (2019). This paper reports that a heathy diet decreases the risk of depression.
Schuch, F. B. et al. Physical activity and incident depression: a meta-analysis of prospective cohort studies. Am. J. Psychiatry 175, 631–648 (2018). This paper reports that physical activity reduces the likelihood of the onset of depression.
Firth, J. et al. A meta-review of “lifestyle psychiatry”: the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders. World Psychiatry 19, 360–380 (2020). This review article presents the importance of investigating the effect of multiple lifestyle factors on the risk of mental disorders.
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This is a summary of: Zhao, Y. et al. The brain structure, immunometabolic and genetic mechanisms underlying the association between lifestyle and depression. Nat. Ment. Health https://doi.org/10.1038/s44220-023-00120-1 (2023).
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Integrated lifestyle factors mitigate depression risk across varied genetic susceptibility. Nat. Mental Health 1, 709–710 (2023). https://doi.org/10.1038/s44220-023-00127-8
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DOI: https://doi.org/10.1038/s44220-023-00127-8
