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Imaging white matter dysfunction in major psychiatric disorders

Nature Mental Health volume 1, pages 613–614 (2023)Cite this article

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Using resting-state functional MRI, we revealed a dysfunction pattern in the white matter of people with four major psychiatric disorders. This pattern is distinct from structural changes and has specific molecular and genetic bases.

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Fig. 1: Dysfunctional WM tracts in major psychiatric disorders.

References

  1. Koshiyam, D. et al. White matter microstructural alterations across four major psychiatric disorders: mega-analysis study in 2937 individuals. Mol. Psychiatry 25, 883–895 (2020). This paper shows the common microstructural changes of WM across psychiatric disorders.

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  2. Ji, G. J. et al. Low-frequency blood oxygen level-dependent fluctuations in the brain white matter: more than just noise. Sci. Bull. 62, 656–657 (2017). This paper shows the importance of functional MRI signals in WM.

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  3. Goodkind, M. et al. Identification of a common neurobiological substrate for mental illness. JAMA Psychiatry 72, 305–315 (2015). This paper shows the common network of different psychiatric disorders.

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  5. Ji, G. J. et al. Regional and network properties of white matter function in Parkinson’s disease. Hum. Brain Mapp. 40, 1253–1263 (2019). This paper reports WM dysfunction in Parkinson’s disease.

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This is a summary of: Ji, G.-J. et al. White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles. Nat. Ment. Health https://doi.org/10.1038/s44220-023-00111-2 (2023).

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Imaging white matter dysfunction in major psychiatric disorders. Nat. Mental Health 1, 613–614 (2023). https://doi.org/10.1038/s44220-023-00121-0

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