We searched for changes in the levels of plasma proteins that could potentially help to identify adolescents at risk of developing mental health issues. Our candidate biomarkers were associated with key enriched biological pathways, including immune responses, blood coagulation, neurogenesis and neuronal degeneration.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$59.00 per year
only $4.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Goodman, A. & Goodman, R. Population mean scores predict child mental disorder rates: validating SDQ prevalence estimators in Britain. J. Child Psychol. Psychiatry 52, 100–108 (2011). This paper presents the rationale for using the SDQ score as an indicator of mental health risk in young individuals.
Madrid-Gambin, F. et al. Integrated lipidomics and proteomics point to early blood-based changes in childhood preceding later development of psychotic experiences: evidence from the Avon longitudinal study of parents and children. Biol Psychiatry 86, 25 (2019). This paper reports potential predictive plasma biomarkers of psychotic experiences in adolescents.
Comes, A. L. et al. Proteomics for blood biomarker exploration of severe mental illness: pitfalls of the past and potential for the future. Transl. Psychiatry 8, 160 (2018). A review article that presents the proteomics approach including methodological challenges for biomarker exploration in the major mental health disorders.
Fernandes, B. S., Dai, Y., Jia, P. & Zhao, Z. Charting the proteome landscape in major psychiatric disorders: from biomarkers to biological pathways towards drug discovery. Eur. Neuropsychopharmacol. 61, 43–59 (2022). A review article that summarizes blood proteomic studies in mental disorders.
Julvez, J. et al. Walnuts, long-chain polyunsaturated fatty acids, and adolescent brain development: protocol for the walnuts smart snack dietary intervention trial. Front Pediatr. 9, (2021). This paper reports the study design of the WALNUTs study.
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This is a summary of: de Sousa Maciel, I. et al. Plasma proteomics discovery of mental health risk biomarkers in adolescents. Nat. Ment. Health https://doi.org/10.1038/s44220-023-00103-2 (2023).
Rights and permissions
About this article
Cite this article
Exploring plasma biomarker candidates for mental health risk assessment in adolescents. Nat. Mental Health 1, 532–533 (2023). https://doi.org/10.1038/s44220-023-00104-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44220-023-00104-1