Myocarditis, an inflammatory heart disease, causes cardiomyocyte loss leading to heart failure. Research now shows that BMP4 is crucial for cardiac tissue homeostasis, and targeted neutralization of BMP inhibitors GREM1 and GREM2 mitigates T cell-induced myocardial inflammation and maintains cardiomyocyte integrity.
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Martín, P. BMP4 mediates myocardial inflammation and fibrosis. Nat Cardiovasc Res 3, 251–253 (2024). https://doi.org/10.1038/s44161-024-00452-w
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DOI: https://doi.org/10.1038/s44161-024-00452-w
