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Ischemia-reperfusion injury

ATF3’s shielding hand to counter ischemia-reperfusion injury in cardiac macrophages

Nature Cardiovascular Research volume 3, pages 15–17 (2024)Cite this article

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Pro-reparative cardiac-resident macrophages have emerged as major players in salvaging the ischemic myocardium of a diseased heart. New research now highlights ATF3 as a key transcription factor that governs macrophage survival and proliferation and myocardial repair.

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Fig. 1: Proposed role of ATF3 in MerTK+ cardiac macrophages after ischemia-reperfusion injury.

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Acknowledgements

The van Rooij lab is supported by funding from the European Union’s Horizon 2020 research and innovation programme (grant agreement 874764 to E.v.R.), and by a fellowship from the ‘La Caixa’ Foundation (grant 100010434 – LCF/BQ/EU23/1201005 to A.C.-M).

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Authors and Affiliations

  1. Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) and University Medical Center Utrecht, Utrecht, Netherlands

    Tim Koopmans, Alejandro Cardona-Monzonís & Eva van Rooij

  2. Department of Cardiology, University Medical Center Utrecht, Utrecht, Netherlands

    Eva van Rooij

Authors
  1. Tim Koopmans
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  2. Alejandro Cardona-Monzonís
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  3. Eva van Rooij
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Correspondence to Eva van Rooij.

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Koopmans, T., Cardona-Monzonís, A. & van Rooij, E. ATF3’s shielding hand to counter ischemia-reperfusion injury in cardiac macrophages. Nat Cardiovasc Res 3, 15–17 (2024). https://doi.org/10.1038/s44161-023-00386-9

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