TREM2 was recently found to have crucial roles in microglia and adipose tissue macrophage function. Research now shows that genetic deletion of macrophage TREM2 modulates lipid uptake, cell death susceptibility and efferocytosis and ultimately reduces experimental atherosclerosis development.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Bouchon, A. et al. Nature 410, 1103–1107 (2001).
Joffre, J. et al. J. Am. Coll. Cardiol. 68, 2776–2793 (2016).
Deczkowska, A. et al. Cell 181, 1207–1217 (2020).
Nugent, A. A. et al. Neuron 105, 837–854 e839 (2020).
Jaitin, D. A. et al. Cell 178, 686–698 e614 (2019).
Hendrikx, T. et al. J. Hepatol. 77, 1373–1385 (2022).
Kim, K. et al. Circ. Res. 123, 1127–1142 (2018).
Patterson, M. T. F. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00354-3 (2023).
Guo, X. et al. Cell. Mol. Life Sci. 80, 137 (2023).
Piollet, M. P. et al. Preprint at bioRxiv https://doi.org/10.1101/2023.05.15.539977 (2023).
Liu, J. et al. Arterioscler. Thromb. Vasc. Biol. 25, 174–179 (2005).
Arai, S. et al. Cell Metab. 1, 201–213 (2005).
Gautier, E. L. et al. Circulation 119, 1795–1804 (2009).
Doran, A. C. et al. Nat. Rev. Immunol. 20, 254–267 (2020).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Riksen, N.P., Ait Oufella, H. Macrophage TREM2 as a new player in atherosclerosis. Nat Cardiovasc Res 2, 1117–1119 (2023). https://doi.org/10.1038/s44161-023-00384-x
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-023-00384-x
