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Cardiac contraction & stiffness

Pinpointing the contributors to myocardial passive stiffness

Nature Cardiovascular Research volume 2, pages 962–963 (2023)Cite this article

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The key determinants of the passive mechanical properties of the heart have long been debated, but remain controversial. Research using a precision approach indicates that titin, microtubules, actin and the extracellular matrix each meaningfully contribute to myocardial passive stiffness in a highly context-dependent manner.

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Fig. 1: The determinants of myocardial passive stiffness.

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Authors and Affiliations

  1. Department of Physiology, Pennsylvania Muscle Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA

    Benjamin L. Prosser

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  1. Benjamin L. Prosser
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Correspondence to Benjamin L. Prosser.

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Competing interests

B.L.P. is an inventor on US patent application no. 15/959,181 USA 2018; composition and methods for improving heart function and treating heart failure.

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Prosser, B.L. Pinpointing the contributors to myocardial passive stiffness. Nat Cardiovasc Res 2, 962–963 (2023). https://doi.org/10.1038/s44161-023-00350-7

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