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Visualizing inflammatory monocytes and macrophages in the human heart

Nature Cardiovascular Research volume 2, pages 869–870 (2023)Cite this article

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Inflammatory monocytes and macrophages in the heart express C-C chemokine receptor 2 (CCR2) on their cell surface and contribute to heart failure pathogenesis. This study established the feasibility of imaging CCR2+ cells by positron emission tomography in patients with myocardial infarction.

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Fig. 1: CCR2 imaging in control individuals and patients with myocardial infarction.

References

  1. Bajpai, G. et al. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat. Med. 24, 1234–1235 (2018). This paper demonstrates the relevance of CCR2+ monocytes and macrophages in the human heart.

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  2. Wienecke, L. M. et al. Imaging targets to visualize the cardiac immune landscape in heart failure. Circ. Cardiovasc. Imaging 16, e014071 (2023). A review article that summarizes immune cells and biomarkers for heart imaging.

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  3. Heo, G. S. et al. Molecular imaging visualizes recruitment of inflammatory monocytes and macrophages to the injured heart. Circ. Res. 124, 881–890 (2019). This paper reports the first CCR2 targeted PET imaging of the injured heart.

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  4. Brody, S. L. et al. Chemokine receptor 2-targeted molecular imaging in pulmonary fibrosis. A clinical trial. Am. J. Respir. Crit. Care Med. 203, 78–89 (2021). This paper reports the first investigation of CCR2 imaging in humans.

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  5. Heo, G. S. et al. Nuclear methods for immune cell imaging: bridging molecular imaging and individualized medicine. Circ. Cardiovasc. Imaging 16, e014067 (2023). A review article that summarizes nuclear approaches for immune cell imaging.

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This is a summary of: Lavine, K. J. et al. CCR2 imaging in human ST-segment elevation myocardial infarction. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-023-00335-6 (2023).

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Visualizing inflammatory monocytes and macrophages in the human heart. Nat Cardiovasc Res 2, 869–870 (2023). https://doi.org/10.1038/s44161-023-00345-4

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