Reduced expression of smooth muscle α-actin (αSMA), a crucial piece of the vascular smooth muscle cell cytoplasmic contractile apparatus, contributes to these cells’ dysfunction in vascular diseases. αSMA is now shown to localize in the nucleus and bind chromatin-remodeling complexes to regulate smooth muscle contractile gene expression.
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This work is supported by US National Institute of Health R01HL146465 to D.G.
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Gomez, D. Beyond the cytoplasm: nuclear α-actin influences differentiation. Nat Cardiovasc Res 2, 864–866 (2023). https://doi.org/10.1038/s44161-023-00343-6
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DOI: https://doi.org/10.1038/s44161-023-00343-6