Modeling complex immune responses to decipher and target the underlying inflammatory mechanisms of atherosclerotic cardiovascular disease (ASCVD) in humans has been challenging. By combining systems immunology-driven drug repurposing with drug functional screens directly in human samples, we identified a new anti-atherosclerotic use for the dual kinase inhibitor saracatinib.
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References
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This is a summary of: Amadori, L. et al. Systems immunology-based drug repurposing framework to target inflammation in atherosclerosis. Nat. Cardiovas. https://doi.org/10.1038/s44161-023-00278-y (2023).
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Systems immunology approach for targeting inflammation in atherosclerosis. Nat Cardiovasc Res 2, 500–501 (2023). https://doi.org/10.1038/s44161-023-00286-y
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DOI: https://doi.org/10.1038/s44161-023-00286-y
