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Myocarditis

Unchecked autoreactive CD8+ T cells wreak havoc in cancer immunotherapy

Nature Cardiovascular Research volume 1, pages 1111–1113 (2022)Cite this article

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Cytotoxic T cells react to cardiac peptides in patients with cancer that receive immunotherapy, resulting in myocarditis. Identifying the targets for T cells in patients who are immunosuppressed will enable a better understanding of individual risk before treatment is initiated

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Fig. 1: CD8+ T cells mature in the thymus and those that recognize self-antigen are deleted via central tolerance mechanisms.

References

  1. Johnson, D. B. et al. Nat. Rev. Clin. Oncol. 19, 254–267 (2022).

    Article  Google Scholar 

  2. Wang, D. Y. et al. JAMA Oncol. 4, 1721–1728 (2018).

    Article  Google Scholar 

  3. Axelrod, M. L. et al. Nature 611, 818–826 (2022).

    Article  CAS  Google Scholar 

  4. Ribas, A. & Wolchok, D. J. Science 359, 1350–1355 (2018).

    Article  CAS  Google Scholar 

  5. Wei, S. C. et al. Cancer Discov. 11, 614–625 (2021).

    Article  CAS  Google Scholar 

  6. Johnson, D. B. et al. New Engl. J. Med. 375, 1749–1755 (2016).

    Article  Google Scholar 

  7. Caforio, A. L. P. et al. Int. J. Cardiol. 179, 166–177 (2015).

    Article  Google Scholar 

  8. Myers, J. M. et al. JCI Insight 1, e85851 (2016).

    Article  Google Scholar 

  9. Gil-Cruz, C. et al. Science 366, 881–886 (2019).

    Article  CAS  Google Scholar 

  10. Lv, H. et al. J. Clin. Invest. 121, 1561–1573 (2011).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Anthony Wong & Slava Epelman

  2. Ted Rogers Centre for Heart Research, Translational Biology and Engineering Program, Toronto, ON, Canada

    Anthony Wong & Slava Epelman

  3. Department of Immunology, University of Toronto, Toronto, ON, Canada

    Anthony Wong & Slava Epelman

  4. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Slava Epelman

  5. Peter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada

    Slava Epelman

Authors
  1. Anthony Wong
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  2. Slava Epelman
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Correspondence to Slava Epelman.

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Wong, A., Epelman, S. Unchecked autoreactive CD8+ T cells wreak havoc in cancer immunotherapy. Nat Cardiovasc Res 1, 1111–1113 (2022). https://doi.org/10.1038/s44161-022-00184-9

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