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Chronopharmacology

Timed use of cardiac glycoside protects the heart

Nature Cardiovascular Research volume 1, pages 973–975 (2022)Cite this article

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Myocardial ischemia–reperfusion injury is more severe during the sleep-to-wake transition period of the day. A new study shows that timed administration of digoxin, a cardiac glycoside approved by the US Food and Drug Administration, prevents experimental myocardial ischemia–reperfusion injury by controlling proteostasis of the circadian-clock regulator Rev-Erbα.

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Fig. 1: Cardioprotection against ischemia–reperfusion injury by timed use of cardiac glycosides.

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Authors and Affiliations

  1. Gene Expression Laboratory, Salk Institute, La Jolla, CA, USA

    Hui J. Wang & Ronald M. Evans

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  1. Hui J. Wang
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  2. Ronald M. Evans
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Correspondence to Ronald M. Evans.

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The authors declare no competing interests.

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Wang, H.J., Evans, R.M. Timed use of cardiac glycoside protects the heart. Nat Cardiovasc Res 1, 973–975 (2022). https://doi.org/10.1038/s44161-022-00158-x

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