Little is known about the maintenance of endothelial cell fate in adults. We show that deletion of Erg and Fli1 in endothelial cells of adult mice causes loss of endothelial cell fate and vascular collapse. Overexpression of ERG and FLI1 in non-vascular cells activates an endothelial cell program, confirming their regulation of endothelial cell identity.
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References
Rafii, S., Butler, J. M. & Ding, B.-S. Angiocrine functions of organ-specific endothelial cells. Nature 529, 316–325 (2016). This review highlights the adaptability of endothelial cells to support the function of each organ, while maintaining their endothelial cell fate.
Ginsberg, M. et al. Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression. Cell 151, 559–575 (2012). This article describes the possibility of direct reprogramming of non-vascular cells into endothelial cells using ETV2, ERG and FLI1 transcription factors.
Asano, Y. et al. Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy. Am. J. Pathol. 176, 1983–1998 (2010). This article demonstrates the importance of FLI1 in endothelial cell function, and suggests a link with the development of vascular maladies.
Birdsey, G. M. et al. The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/β-catenin signaling. Dev. Cell 32, 82–96 (2015). This article underscores the importance of ERG during vascular development and links vascular stability with the control of WNT signaling in the endothelium.
Kalna, V. et al. The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program. Circ. Res. 124, 1337–1349 (2019). This article demonstrates the role of ERG in the control of vascular gene expression through epigenetic regulation of super-enhancers.
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This is a summary of: Gomez-Salinero, G. M. et al. Cooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis. Nat. Cardiovas. Res. https://doi.org/10.1038/s44161-022-00128-3 (2022).
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Adult endothelium cell fate is maintained by ERG and FLI1. Nat Cardiovasc Res 1, 880–881 (2022). https://doi.org/10.1038/s44161-022-00144-3
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DOI: https://doi.org/10.1038/s44161-022-00144-3
