Recent developments in high-throughput, in-depth sequencing platforms are providing opportunities to improve our understanding of biology and disease. Here, Kuppe et al. use a combinatorial approach to relate transcriptional changes to translational and functional implications for the heart in response to myocardial infarction.
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References
Litviňuková, M. et al. Nature 588, 466–472 (2020).
Wehrens, M. et al. Cell Rep. 39, 6 (2022).
Chaffin, M. et al. Nature 608, 174–180 (2022).
Wang, L. et al. Nat. Cell Biol. 22, 108–119 (2020).
Nomura, S. et al. Nat. Commun. 9, 4435 (2018).
Elowitz, M. B. et al. Science 297, 1183–1186 (2002).
Molenaar, B. et al. Commun. Biol. 4, 146 (2021).
Kuppe, C. et al. Nature https://doi.org/10.1038/s41586-022-05060-x (2022).
Kuppe, C. et al. Nature 589, 281–286 (2021).
Regev, A. et al. eLife 6, e27041 (2017).
Barrett, T. et al. Nucleic Acids Res. 41, 991–995 (2013).
Acknowledgements
This work has received funding from the European Union’s Horizon 2020 research and innovation programme under the grant agreement no. 874764 (REANIMA) and was supported by the Dutch Cardiovascular Alliance (DCVA), an initiative with support of the Dutch Heart Foundation, DCVA2017-18 ARENA-PRIME.
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Wehrens, M., Timmer, L.T. & van Rooij, E. High-throughput methods to help understand heart disease. Nat Cardiovasc Res 1, 798–799 (2022). https://doi.org/10.1038/s44161-022-00126-5
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DOI: https://doi.org/10.1038/s44161-022-00126-5
