Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

HEMATOPOIESIS

Modeling the temporal dynamics of clonal hematopoiesis

Nature Cardiovascular Research volume 1, pages 537–538 (2022)Cite this article

Subjects

Clonal hematopoiesis is a risk factor for hematological cancers, cardiovascular diseases and death. Two papers now use new experimental and mathematical tools to quantify changes in the clonal composition of human blood over time, and the results have implications for the risk of cardiovascular diseases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Somatic mutations in HSCs lead to a proliferative advantage and clonal expansion.

References

  1. Lee-Six, H. et al. Nature 561, 473–478 (2018).

    Article  CAS  Google Scholar 

  2. Steensma, D. P. et al. Blood 126, 9–16 (2015).

    Article  CAS  Google Scholar 

  3. Bick, A. G. et al. Nature 586, 763–768 (2020).

    Article  CAS  Google Scholar 

  4. Jaiswal, S. et al. N. Engl. J. Med. 371, 2488–2498 (2014).

    Article  Google Scholar 

  5. Niroula, A. et al. Nat. Med. 27, 1921–1927 (2021).

    Article  CAS  Google Scholar 

  6. Jaiswal, S. et al. N. Engl. J. Med. 377, 111–121 (2017).

    Article  Google Scholar 

  7. Bick, A. G. et al. Circulation 141, 124–131 (2020).

    Article  CAS  Google Scholar 

  8. Bhattacharya, R. et al. Stroke 53, 788–797 (2022).

    Article  CAS  Google Scholar 

  9. Yu, B. et al. J. Am. Coll. Cardiol. 78, 42–52 (2021).

    Article  CAS  Google Scholar 

  10. Mitchell, E. et al. Nature https://doi.org/10.1038/s41586-022-04786-y (2022).

    Article  PubMed  PubMed Central  Google Scholar 

  11. Fabre, M. A. et al. Nature https://doi.org/10.1038/s41586-022-04785-z (2022).

  12. Williams, N. et al. Nature 602, 162–168 (2022).

    Article  CAS  Google Scholar 

  13. Van Egeren, D. et al. Cell Stem Cell 28, 514–523.e9 (2021).

    Article  Google Scholar 

  14. Yvan-Charvet, L. et al. Science 328, 1689–1693 (2010).

    Article  CAS  Google Scholar 

  15. Heyde, A. et al. Cell 184, 1348–1361.e22 (2021).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology & Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA

    Siddhartha Jaiswal

  2. Department of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA

    Alexander G. Bick

Authors
  1. Siddhartha Jaiswal
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Alexander G. Bick
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Siddhartha Jaiswal.

Ethics declarations

Competing interests

S.J. is a consultant to Novartis, Roche Genentech, AVRO Bio and Foresite Labs, and on the scientific advisory board for Bitterroot Bio. S.J. and A.G.B. are founders and equity holders of TenSixteen Bio.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jaiswal, S., Bick, A.G. Modeling the temporal dynamics of clonal hematopoiesis. Nat Cardiovasc Res 1, 537–538 (2022). https://doi.org/10.1038/s44161-022-00086-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44161-022-00086-w

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing