Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Synthetic methodology

Nickel and light combine for amine synthesis

The combination of photocatalysis and nickel catalysis enables the multicomponent synthesis of N-alkyl anilines through tandem C–N transposition and C–H alkylation of alkylamines.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: A selective three-component synthesis of N-alkyl anilines.

References

  1. Afanasyev, O. I., Kuchuk, E., Usanov, D. L. & Chusov, D. Chem. Rev. 119, 11857–11911 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Ruiz-Castillo, P. & Buchwald, S. L. Chem. Rev. 116, 12564–12649 (2016).

    Article  CAS  PubMed  Google Scholar 

  3. He, C., Whitehurst, W. G. & Gaunt, M. J. Chem 5, 1031–1058 (2019).

    Article  CAS  Google Scholar 

  4. Liu, R. Y. & Buchwald, S. L. Acc. Chem. Res. 53, 1229–1243 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Garrido-Castro, A. F., Maestro, M. C. & Alemán, J. Catalysts 10, 562 (2020).

    Article  CAS  Google Scholar 

  6. Rivas, M., Palchykov, V., Jia, X. & Gevorgyan, V. Nat. Rev. Chem. 6, 544–561 (2022).

    Article  PubMed Central  Google Scholar 

  7. Kumar, R., Flodén, N. J., Whitehurst, W. G. & Gaunt, M. J. Nature 581, 415–420 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Jiang, H., Seidler, G. & Studer, A. Angew. Chem. Int. Ed. 131, 16680–16684 (2019).

    Article  Google Scholar 

  9. Zhang, Z.-W., Feng, Z., Ma, J.-A. & Cheung, C. W. Nat. Synth. https://doi.org/10.1038/s44160-023-00370-y (2023).

    Article  Google Scholar 

  10. Chan, A. Y. et al. Chem. Rev. 122, 1485–1542 (2022).

    Article  CAS  PubMed  Google Scholar 

  11. Jin, C., Decker, A. M., Harris, D. L. & Blough, B. E. ACS Chem. Neurosci. 7, 1418–1432 (2016).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Leifeng Wang.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, L. Nickel and light combine for amine synthesis. Nat. Synth 2, 1129–1131 (2023). https://doi.org/10.1038/s44160-023-00377-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s44160-023-00377-5

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing