A strategy for the transition-metal-free C(sp2)−C(sp3) cross-coupling of α-(pseudo)halo aliphatic ketones and arylboronic acids via a 1,4-metallate shift is demonstrated. The reaction proceeds under mild conditions in the presence of base, and offers an operationally simple method for the construction of C(sp2)−C(sp3) bonds.
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References
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This is a summary of: Li, X. et al. Transition-metal-free C(sp2)–C(sp3) cross-coupling of α-(pseudo)halo aliphatic ketones with boronic acids via a 1,4-metallate shift. Nat. Synth. https://doi.org/10.1038/s44160-023-00373-9 (2023).
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Synthesis of α-aryl ketones through transition-metal-free cross-coupling. Nat. Synth 2, 1138–1139 (2023). https://doi.org/10.1038/s44160-023-00374-8
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DOI: https://doi.org/10.1038/s44160-023-00374-8
