Chiral macrocycles are of interest for various applications, including drug discovery, but are challenging to synthesize. Now, a method for enantiocontrolled macrocyclization is demonstrated, involving the confinement of a linear substrate within a self-assembled chiral capsule. This method shows good substrate scope and affords chiral macrocycles with high enantioselectivities and conversions.
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References
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This is a summary of: Tan, L. et al. Enantiocontrolled macrocyclization by encapsulation of substrates in chiral capsules. Nat. Synth. https://doi.org/10.1038/s44160-023-00360-0 (2023).
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Chiral macrocycle formation within chiral capsules. Nat. Synth 2, 1140–1141 (2023). https://doi.org/10.1038/s44160-023-00361-z
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DOI: https://doi.org/10.1038/s44160-023-00361-z
