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Homogeneous catalysis

A change of direction through trans-bis-silylation of alkynes

Nature Synthesis volume 2, pages 902–903 (2023)Cite this article

The activation of a Si–Si bond and its subsequent trans-addition across an alkyne substrate is a challenge. Now, a Pd-catalysed process for the trans-bis-silylation of terminal alkynes is reported, using a quinoline-substituted disilane reagent.

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Fig. 1: Pd-catalysed trans-bis-silylation of terminal alkynes.

References

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  1. Twitter: @JSpencerlab

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  1. Sussex Drug Discovery Centre, Department of Chemistry, School of Life Sciences, University of Sussex, Brighton, UK

    John Spencer

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  1. John Spencer
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Correspondence to John Spencer.

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Spencer, J. A change of direction through trans-bis-silylation of alkynes. Nat. Synth 2, 902–903 (2023). https://doi.org/10.1038/s44160-023-00355-x

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