The most popular reactions used by medicinal chemists are often incompatible with nanoscale ultrahigh-throughput experimentation (ultraHTE). Now, a set of ultraHTE-amenable reaction conditions is reported for four of the most important transformations in drug discovery, and their generality and scalability tested on a range of complex natural products and drug candidates.
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References
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This is a summary of: Gesmundo, N. et al. Miniaturization of popular reactions from the medicinal chemists’ toolbox for ultrahigh-throughput experimentation. Nat. Synth. https://doi.org/10.1038/s44160-023-00351-1 (2023).
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A miniaturized toolkit for medicinal chemists. Nat. Synth 2, 1018–1019 (2023). https://doi.org/10.1038/s44160-023-00352-0
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DOI: https://doi.org/10.1038/s44160-023-00352-0