Cyclic iminium salts are used as versatile intermediates in the synthesis of diverse N-(hetero)aryl piperidines. This method facilitates the C2 and/or C3 functionalization of the piperidine backbone with motifs relevant to medicinal chemistry, enabling the exploration of previously inaccessible chemical space for the discovery of medicines.
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This is a summary of: Greenwood, J. W. et al. Isolable iminium ions as a platform for N-(hetero)aryl piperidine synthesis. Nat. Synth. https://doi.org/10.1038/s44160-023-00313-7 (2023).
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Isolable iminium salts enable access to elusive piperidines. Nat. Synth 2, 1014–1015 (2023). https://doi.org/10.1038/s44160-023-00314-6
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DOI: https://doi.org/10.1038/s44160-023-00314-6
